Sputnik V effective against Omicron, say developers

According to the researchers, increasing sputnik light as part of the “Mix and Match” approach can help overcome the efficacy of lower mRNA vaccines against omicrons and documented, quickly, the efficacy of the MRNA vaccine against Covid-19.

The anti-Covid-19 Russian vaccine, Sputnik V, has twice higher viruses neutralizing antibodies for omicron variants rather than the Pfizer vaccine, announcing the developer on Wednesday based on Prefrint studies.

“A unique independent comparison study conducted at the National Institute for Diseases Infectious Lazzaro Spallanzani (Italy) by the team with the researchers of the Institute and Gamaleya Center show that the 2 doses of Sputnik v provide more than 2 times the higher average geometric titers (GMT) The virus neutralizes antibodies in the Omicron Covid variant rather than 2 doses of PFIZER vaccines (a total of 2.1 times higher and 2.6 times higher 3 months after vaccination), “said the developer of vaccines, Gamaleya Center and Russian direct investment funds, in a statement .

According to the researchers, increasing sputnik light as part of the “Mix and Match” approach can help overcome the efficacy of lower mRNA vaccines against omicrons and documented, quickly, the efficacy of the MRNA vaccine against Covid-19. The partnership between adenoviral and MRNA vaccines can provide stronger protection against Omicron and other variants.

Sputnik Light is the first component of the v two-dose Sputnik vaccine.

“Based on data collected by the Institute and Spallanzani results and the results of previous studies, heterologous (” mix & match “) increasing with Sputnik Light is the best solution to increase other vaccine efficacy and expand the booster protection period as an optimal adenoviral platform configuration provides more protection Whether against Omicron and other mutations … “Read the statement.

The developer also said that Sputnik Light has shown strong results as a booster in the trial “Mix and Match” in Argentina. The combination of sputnik light with vaccines produced by AstraZeneca, Sinopharm, Modername and Cansino, carried out in 5 provinces (City and Province of Buenos Aires, and Córdoba, La Rioja and San Luis) have shown that sputnik light induces stronger antibodies and t -cell response compared to homologous regimens (two same vaccine shots).

“Combined studies confirm the results obtained in our separate studies published in December 2021. Hard Swastic data proves that Sputnik V has a higher viral neutralization activity against Omicron compared to other vaccines and will play a major role in global fight against this challenging variant, “Alexander Gintsburg said, Director, Gamaleya Center.

Each combination of cocktail vaccines with sputnik light provides higher antibody titers on the 14th day after giving the second dose when compared to original homologies (the same vaccine as the first and second dose) of each vaccine.

“Because the duration of vaccine protection is to avoid a frequent increase, the author of other studies in Argentina has noted that the protection of Coronavirus remains stable after vaccination with Russian V Sputnik vaccines as a consequence of the maturation of antibodies that are enhanced by the virus. Escape mutations,” the researchers said newspaper.